Towards this goal, we have established a family-based genetic study of severe mental illness using linkage-based exome sequencing and induced pluripotent stem cell modeling, collaborated in the ascertainment of the largest prospective cohort in the world of women with first-onset postpartum psychosis, and continued leveraging mouse models for understanding the molecular and cellular mechanisms of genetically-defined neuropsychiatric disorders.
To date, we have participated in important collaborative studies of translational models of neuropsychiatric disorders regarding postpartum psychosis, schizophrenia, Angelman Syndrome and Neurofibromatosis type I.
Most recently, we have elucidated novel familial exome variants associated with depression and schizophrenia in which human induced pluripotent stem cell modeling revealed an important contribution of glial cell biology to the underlying disease pathophysiology. Steven Kushner.
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The cationic peptide facilitates electrostatic interactions between the DNA and the peptide, and the nuclear localization sequence utilizes the endogenous nuclear transport machinery to deliver the DNA to the nucleus.
The end result is high efficiency transfection in non-dividing cells. A peptide based reagent combines a non-classical nuclear localization sequence M9 with a nucleotide binding domain, to help transport DNA into the transfected cell's nucleus. Research sheds new light into the molecular basis of bipolar disorder November 25 Tags: Molecular Biology , Neuroscience Tweet.
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